S-acetyl-PEG4-alcohol

Modify Date: 2024-01-05 18:55:53

S-acetyl-PEG4-alcohol Structure
S-acetyl-PEG4-alcohol structure
Common Name S-acetyl-PEG4-alcohol
CAS Number 223611-42-5 Molecular Weight 252.32800
Density N/A Boiling Point N/A
Molecular Formula C10H20O5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of S-acetyl-PEG4-alcohol


S-acetyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name S-11-hydroxy-3,6,9-trioxaundecyl ethanethioate
Synonym More Synonyms

 S-acetyl-PEG4-alcohol Biological Activity

Description S-acetyl-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C10H20O5S
Molecular Weight 252.32800
Exact Mass 252.10300
PSA 90.29000
LogP 0.30820

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

11-thioacetate-3,6,9-trioxa-undecan-1-ol
tetraethylene glycol monothioacetate
S-acetyl-PEG4-alcohol
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