Tubulin inhibitor 35

Modify Date: 2024-01-23 16:50:49

Tubulin inhibitor 35 Structure
Tubulin inhibitor 35 structure
Common Name Tubulin inhibitor 35
CAS Number 2247047-77-2 Molecular Weight 331.41
Density N/A Boiling Point N/A
Molecular Formula C21H21N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Tubulin inhibitor 35


Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines,and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines)[1].

 Names

Name Tubulin inhibitor 35

 Tubulin inhibitor 35 Biological Activity

Description Tubulin inhibitor 35 (compound 6b) is a dual inhibitor of topoisomerase I (IC50=~50 μM) and tubulin polymerization (IC50=5.69 μM). Tubulin inhibitor 35 inhibits migration and invasion of MGC-803 and RKO cell lines,and induces apoptosis via arresting cell cycle at G2/M phase. Tubulin inhibitor 35 exhibis potent efficacy in gastrointestinal tumor inhibiton (inhibits MGC-803 (IC50=0.09 μM) and RKO (IC50=0.2 μM) cell lines)[1].
Related Catalog
References

[1]. Deng J, et al. N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents. Eur J Med Chem. 2023 Jul 5;255:115366.  

 Chemical & Physical Properties

Molecular Formula C21H21N3O
Molecular Weight 331.41