DDO-7263

Modify Date: 2024-01-09 00:49:53

DDO-7263 Structure
DDO-7263 structure
Common Name DDO-7263
CAS Number 2254004-96-9 Molecular Weight 273.24
Density N/A Boiling Point N/A
Molecular Formula C14H9F2N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DDO-7263


DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2 activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity[1].

 Names

Name DDO-7263

 DDO-7263 Biological Activity

Description DDO-7263, a 1,2,4-Oxadiazole derivative, is a potent Nrf2 activator. DDO-7263 upregulates Nrf2 through binding to Rpn6 to block the assembly of 26S proteasome and the subsequent degradation of ubiquitinated Nrf2. DDO-7263 activates the Nrf2-ARE signaling pathway and exerts anti-inflammatory activity[1].
Related Catalog
References

[1]. Zhen Dai, et al. Target Fishing Reveals a Novel Mechanism of 1,2,4-Oxadiazole Derivatives Targeting Rpn6, a Subunit of 26S Proteasome. J Med Chem. 2022 Mar 24;65(6):5029-5043.

 Chemical & Physical Properties

Molecular Formula C14H9F2N3O
Molecular Weight 273.24