SJFα

Modify Date: 2024-10-11 18:55:00

SJFα structure	Common Name	SJFα
	CAS Number	2254609-27-1	Molecular Weight	1120.27
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₅₉H₆₇F₂N₇O₁₁S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SJFα

SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].

Name	SJFα

Description	SJFα is a 13-atom linker PROTAC. SJFα degrades p38α with a DC50 of 7.16 nM, but is far less effective at degrading p38δ (DC50=299 nM) and does not degrade the other p38 isoforms (β and γ) at concentrations up to 2.5 µM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Signaling Pathways >> PROTAC >> PROTAC
Target	p38α:7.16 nM (DC50) p38δ:299 nM (DC50) PROTAC
References	[1]. Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10(1):131.

Molecular Formula	C₅₉H₆₇F₂N₇O₁₁S
Molecular Weight	1120.27

Hazard Codes	Xi

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: SJFα
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