Peimine

Modify Date: 2024-01-02 16:28:02

Peimine Structure
Peimine structure
Common Name Peimine
CAS Number 23496-41-5 Molecular Weight 431.651
Density 1.2±0.1 g/cm3 Boiling Point 568.4±50.0 °C at 760 mmHg
Molecular Formula C27H45NO3 Melting Point 233-234ºC
MSDS Chinese USA Flash Point 275.3±28.8 °C

 Use of Peimine


Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.

 Names

Name Peimine
Synonym More Synonyms

 Peimine Biological Activity

Description Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.
Related Catalog
References

[1]. Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 568.4±50.0 °C at 760 mmHg
Melting Point 233-234ºC
Molecular Formula C27H45NO3
Molecular Weight 431.651
Flash Point 275.3±28.8 °C
Exact Mass 431.339935
PSA 63.93000
LogP 4.45
Vapour Pressure 0.0±3.5 mmHg at 25°C
Index of Refraction 1.591
Storage condition 2-8℃

 Safety Information

Hazard Codes Xi
Safety Phrases 24/25
RIDADR NONH for all modes of transport

 Synthetic Route

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Peimine Structure

Peimine

CAS#:23496-41-5

Literature: Heterocycles, , vol. 15, # 2 p. 791 - 796

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Peimine Structure

Peimine

CAS#:23496-41-5

Literature: Chemical & Pharmaceutical Bulletin, , vol. 28, # 4 p. 1345 - 1346

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

Peimine
Isodihydroimperialin
5α-Cevane-3β,6α,20-triol
verticine
(3β,5α,6α)-Cevane-3,6,20-triol
Verticine,Zhebeinine,Wanpeinine A
ISODIHYDROIMPERIALINE
Dihydroisoimperialine
(3b,5a,6a)-cevane-3,6,20-triol
cevane-3,6,20-triol, (3b,5a,6a)-
Cevane-3,6,20-triol, (3β,5α,6α)-
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