23496-41-5

23496-41-5 structure

Name: Peimine
Chemical Name: Peimine
CAS Number: 23496-41-5
Molecular Formula: C₂₇H₄₅NO₃
Molecular Weight: 431.651
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-10-03 16:16:33
Modify Date: 2024-01-02 16:28:02
Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.

Name	Peimine
Synonyms	Peimine Isodihydroimperialin 5α-Cevane-3β,6α,20-triol verticine (3β,5α,6α)-Cevane-3,6,20-triol Verticine,Zhebeinine,Wanpeinine A ISODIHYDROIMPERIALINE Dihydroisoimperialine (3b,5a,6a)-cevane-3,6,20-triol cevane-3,6,20-triol, (3b,5a,6a)- Cevane-3,6,20-triol, (3β,5α,6α)-

Description	Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo.IC50 value:Target:Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Inflammation/Immunology
References	[1]. Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport

77410-34-5

23496-41-5

Literature: Heterocycles, , vol. 15, # 2 p. 791 - 796

74170-33-5

23496-41-5

Literature: Chemical & Pharmaceutical Bulletin, , vol. 28, # 4 p. 1345 - 1346

Precursor 2
77410-34-5 74170-33-5
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