Captopril EP Impurity E

Modify Date: 2024-01-10 18:45:20

Captopril EP Impurity E Structure
Captopril EP Impurity E structure
Common Name Captopril EP Impurity E
CAS Number 23500-15-4 Molecular Weight 185.22000
Density N/A Boiling Point N/A
Molecular Formula C9H15NO3 Melting Point 122.6-123.7℃
MSDS N/A Flash Point N/A

 Use of Captopril EP Impurity E


Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

 Names

Name (2S)-1-(2-methylpropanoyl)pyrrolidine-2-carboxylic acid
Synonym More Synonyms

 Captopril EP Impurity E Biological Activity

Description Captopril EP Impurity E is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog
References

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

 Chemical & Physical Properties

Melting Point 122.6-123.7℃
Molecular Formula C9H15NO3
Molecular Weight 185.22000
Exact Mass 185.10500
PSA 57.61000
LogP 0.65590

 Synonyms

L-Proline,1-(2-methyl-1-oxopropyl)
(2S)-1-(2-Methylpropanoyl)pyrrolidine-2-carboxylic acid,1-Isobutyryl-L-proline
UNII-27JC6R80S1
L-1-Isobutyrylproline
Captopril Impurity 6
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