Captopril EP Impurity B

Modify Date: 2024-01-02 11:26:20

Captopril EP Impurity B Structure
Captopril EP Impurity B structure
 Common Name Captopril EP Impurity B
CAS Number 80629-35-2 Molecular Weight 264.11600
Density 1.555±0.06 g/cm3 (20 ºC 760 Torr) Boiling Point N/A
Molecular Formula C9H14BrNO3 Melting Point 110-114 ºC
MSDS N/A Flash Point N/A

 Use of Captopril EP Impurity B


Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].

 Names

Name 1-(3-bromo-2S-methylpropionyl)-pyrrolidine-2S-carboxylic acid
Synonym More Synonyms

 Captopril EP Impurity B Biological Activity

Description Captopril EP Impurity B is an impurity of Captopril. Captopril (SQ-14534), antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM)[1][2][3].
Related Catalog
References

[1]. ANCA GABRIELA CÂRJE, et al. HPLC-UV METHOD APPROACH FOR THE ANALYSIS AND IMPURITY PROFILING OF CAPTOPRIL.

[2]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268.

[3]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35.

 Chemical & Physical Properties

Density 1.555±0.06 g/cm3 (20 ºC 760 Torr)
Melting Point 110-114 ºC
Molecular Formula C9H14BrNO3
Molecular Weight 264.11600
Exact Mass 263.01600
PSA 57.61000
LogP 1.03090

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

1-[(2S)-3-Bromo-2-methyl-1-oxopropyl]-L-proline
Captopril EP Impurity B
Captopril Impurity 2
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