DM-01
Modify Date: 2024-01-02 17:46:19
DM-01 structure
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Common Name | DM-01 | ||
|---|---|---|---|---|
| CAS Number | 2355280-00-9 | Molecular Weight | 431.45 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H24F3N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DM-01DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1]. |
| Name | DM-01 |
|---|
| Description | DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1]. |
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| Related Catalog | |
| Target |
EZH2 |
| In Vitro | Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μΜ[1]. DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells[1]. DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2[1]. Cell Viability Assay[1] Cell Line: A549 sh-EV and A549 sh-EZH2 cells Concentration: 1, 5, 10, 50, 100 μM Incubation Time: 48 hours Result: The IC50s of 72.748 and 269.7 μΜ for A549 sh-EV and A549 sh-EZH2 cells, respectively. Western Blot Analysis[1] Cell Line: K562 cells Concentration: 5, 10 μM Incubation Time: 24 hours Result: Inhibited the activity of EZH2 and resulted in abolished H3K27me expression. |
| References |
| Molecular Formula | C23H24F3N3O2 |
|---|---|
| Molecular Weight | 431.45 |