2355280-00-9
2355280-00-9 structure
- Name: DM-01
- Chemical Name: DM-01
- CAS Number: 2355280-00-9
- Molecular Formula: C23H24F3N3O2
- Molecular Weight: 431.45
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2020-08-09 17:01:37
- Modify Date: 2024-01-02 17:46:19
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DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1].
| Name | DM-01 |
|---|
| Description | DM-01 is a powerful and selective EZH2 inhibitor for the research of diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), and SNF5/INI-1/SMARCB1 genetically defined solid tumors[1]. |
|---|---|
| Related Catalog | |
| Target |
EZH2 |
| In Vitro | Knockdown EZH2 in A549 cells results in the decrease of cell sensitivity to DM-01 at 50 and 100 μM concentrations. DM-01 also shows comparable inhibitory activity for K562 cells with an IC50 value of 58.706 μΜ[1]. DM-01 (5 and 10 μM; 24 hours) strongly inhibits the activity of EZH2 and results in abolished H3K27me expression in K562 cells[1]. DM-01 (5 and 10 μM) also increases the transcription expression of DIRAS3 in a dose dependent manner, a tumor suppressor in downstream of EZH2[1]. Cell Viability Assay[1] Cell Line: A549 sh-EV and A549 sh-EZH2 cells Concentration: 1, 5, 10, 50, 100 μM Incubation Time: 48 hours Result: The IC50s of 72.748 and 269.7 μΜ for A549 sh-EV and A549 sh-EZH2 cells, respectively. Western Blot Analysis[1] Cell Line: K562 cells Concentration: 5, 10 μM Incubation Time: 24 hours Result: Inhibited the activity of EZH2 and resulted in abolished H3K27me expression. |
| References |
| Molecular Formula | C23H24F3N3O2 |
|---|---|
| Molecular Weight | 431.45 |