As-358 hydrochloride

Modify Date: 2024-01-09 14:25:41

As-358 hydrochloride Structure
As-358 hydrochloride structure
Common Name As-358 hydrochloride
CAS Number 2374723-26-7 Molecular Weight 329.91
Density N/A Boiling Point N/A
Molecular Formula C18H32ClNO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of As-358 hydrochloride


As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].

 Names

Name As-358 hydrochloride

 As-358 hydrochloride Biological Activity

Description As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].
Related Catalog
Target

IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1]

In Vitro As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1]. Cell Proliferation Assay Cell Line: Vero (infected with EBOV and MARV)[1] Concentration: 0-500 μM Incubation Time: 10 days Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
In Vivo As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1]. Animal Model: ICR mice[1] Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg Administration: IG; single (observed for 7 days) Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
References

[1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726.

 Chemical & Physical Properties

Molecular Formula C18H32ClNO2
Molecular Weight 329.91