Agarospirol structure
|
Common Name | Agarospirol | ||
---|---|---|---|---|
CAS Number | 23811-08-7 | Molecular Weight | 222.366 | |
Density | 1.0±0.1 g/cm3 | Boiling Point | 312.2±11.0 °C at 760 mmHg | |
Molecular Formula | C15H26O | Melting Point | 59-60°C (lit.) | |
MSDS | N/A | Flash Point | 114.6±15.6 °C |
Use of Agarospirol(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1]. |
Name | hinesol |
---|---|
Synonym | More Synonyms |
Description | (-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1]. |
---|---|
Related Catalog | |
In Vitro | (-)-Hinesol (0-25 µg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change for the total protein levels of IκBα and p65 in A549 cells[1]. Cell Proliferation Assay[1] Cell Line: A549, NCI-H1299 cells Concentration: 0-25 µg/ml Incubation Time: 24, 48 h Result: Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Induced apoptosis with the apoptotic cells was increased to 21.2 ± 0.96% and 36 ± 1.04% after treatment with hinesol at 2 and 8 μg/mL, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Increased the protein expression of Bax and decreased the expression of Bcl-2. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase. |
References |
Density | 1.0±0.1 g/cm3 |
---|---|
Boiling Point | 312.2±11.0 °C at 760 mmHg |
Melting Point | 59-60°C (lit.) |
Molecular Formula | C15H26O |
Molecular Weight | 222.366 |
Flash Point | 114.6±15.6 °C |
Exact Mass | 222.198364 |
PSA | 20.23000 |
LogP | 4.67 |
Vapour Pressure | 0.0±1.5 mmHg at 25°C |
Index of Refraction | 1.505 |
HS Code | 2906199090 |
---|
HS Code | 2906199090 |
---|---|
Summary | 2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0% |
2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]propan-2-ol |
Agarospirol |
Spiro[4.5]dec-6-ene-2-methanol, α,α,6,10-tetramethyl-, (2S,5R,10R)- |
2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]-2-propanol |