Nrf2 activator-4

Modify Date: 2024-01-08 17:46:08

Nrf2 activator-4 structure	Common Name	Nrf2 activator-4
	CAS Number	2383016-68-8	Molecular Weight	468.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₄ClF₃N₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Nrf2 activator-4

Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].

Name	Nrf2 activator-4

Description	Nrf2 activator-4 (Compound 20a) is a highly potent, orally active Nrf2 activator with an EC50 of 0.63 µM. Nrf2 activator-4 suppresses reactive oxygen species against oxidative stress in microglia. Nrf2 activator-4 effectively recovers the learning and memory impairment in a scopolamine-induced mouse model[1].
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Signaling Pathways >> Protein Tyrosine Kinase/RTK >> ROS Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	EC50: 0.63 µM (Nrf2)[1]
References	[1]. Kim HJ, et al. A novel chalcone derivative as Nrf2 activator attenuates learning and memory impairment in a scopolamine-induced mouse model. Eur J Med Chem. 2020 Jan 1;185:111777.

Molecular Formula	C₂₃H₂₄ClF₃N₂O₃
Molecular Weight	468.90

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Nrf2 activator-4
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