TGFβ-IN-2

Modify Date: 2024-04-08 18:54:23

TGFβ-IN-2 structure	Common Name	TGFβ-IN-2
	CAS Number	2387678-02-4	Molecular Weight	378.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₂N₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TGFβ-IN-2

TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].

Name	TGFβ-IN-2

Description	TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC50 of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> TGF-beta/Smad Signaling Pathways >> TGF-beta/Smad >> TGF-beta/Smad Research Areas >> Inflammation/Immunology
References	[1]. Dexin Deng, et al. Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis. Eur J Med Chem. 2020 Jan 1;185:111790.

Molecular Formula	C₂₂H₂₂N₂O₄
Molecular Weight	378.42

TGFβ-IN-2

Use of TGFβ-IN-2

Names

TGFβ-IN-2 Biological Activity

Chemical & Physical Properties