PD-1/PD-L1-IN 6

Modify Date: 2024-01-06 11:24:04

PD-1/PD-L1-IN 6 Structure
PD-1/PD-L1-IN 6 structure
Common Name PD-1/PD-L1-IN 6
CAS Number 2393983-76-9 Molecular Weight 402.49
Density N/A Boiling Point N/A
Molecular Formula C25H26N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PD-1/PD-L1-IN 6


PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].

 Names

Name PD-1/PD-L1-IN 6

 PD-1/PD-L1-IN 6 Biological Activity

Description PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].
Related Catalog
Target

IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)

References

[1]. Qin M, et al. Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold. Eur J Med Chem. 2020 Jan 15;186:111856.

 Chemical & Physical Properties

Molecular Formula C25H26N2O3
Molecular Weight 402.49