2393983-76-9

2393983-76-9 structure

Name: PD-1/PD-L1-IN 6
Chemical Name: PD-1/PD-L1-IN 6
CAS Number: 2393983-76-9
Molecular Formula: C₂₅H₂₆N₂O₃
Molecular Weight: 402.49
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2022-08-03 21:08:46
Modify Date: 2024-01-06 11:24:04
PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].

Name	PD-1/PD-L1-IN 6

Description	PD-1/PD-L1-IN 6 (compound A13) is a potent PD-1/PD-L1 interaction inhibitor, with an IC50 of 132.8 nM. PD-1/PD-L1-IN 6 exhibits outstanding immunoregulatory activity. PD-1/PD-L1-IN 6 significantly elevates interferon-γ secretion in a Hep3B/OS-8/hPD-L1 and CD3 T cell co-culture model, without significant toxic effect. PD-1/PD-L1-IN 6 restores the immune response in a T cell-tumor co-culture model[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1 Research Areas >> Inflammation/Immunology
Target	IC50: 132.8 ± 6.9 nM (PD-1/PD-L1 interaction)
References	[1]. Qin M, et al. Discovery of the programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing an indoline scaffold. Eur J Med Chem. 2020 Jan 15;186:111856.

Molecular Formula	C₂₅H₂₆N₂O₃
Molecular Weight	402.49