Thymidine-13C-1

Modify Date: 2024-01-18 08:16:56

Thymidine-13C-1 Structure
Thymidine-13C-1 structure
Common Name Thymidine-13C-1
CAS Number 240407-53-8 Molecular Weight 243.22100
Density N/A Boiling Point N/A
Molecular Formula C10H14N2O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thymidine-13C-1


Thymidine-13C-1 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]

 Names

Name 1-[(2R,4S,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

 Thymidine-13C-1 Biological Activity

Description Thymidine-13C-1 is the 13C labeled Thymidine. Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication[1]
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Chen G, et al. Cell Synchronization by Double Thymidine Block. Bio Protoc. 2018 Sep 5;8(17).;FIRKET H, et al. Autoradiographic visualization of synthesis of deoxyribonucleic acid in tissue culture with tritium-labelled thymidine. Nature. 1958 Jan 24;181(4

 Chemical & Physical Properties

Molecular Formula C10H14N2O5
Molecular Weight 243.22100
Exact Mass 243.09400
PSA 104.55000