2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
![2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid Structure](https://image.chemsrc.com/caspic/124/2410-93-7.png)
2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid structure
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Common Name | 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid | ||
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| CAS Number | 2410-93-7 | Molecular Weight | 455.42400 | |
| Density | 1.61g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C20H21N7O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic AcidMethopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis[1]. |
| Name | L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]methylamino]benzoyl]- |
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| Synonym | More Synonyms |
| Description | Methopterin inhibits osteoclasts proliferation. Methopterin inhibits the activation and bone resorption function of osteoclasts, and induced osteoclasts apoptosis[1]. |
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| Related Catalog | |
| References |
| Density | 1.61g/cm3 |
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| Molecular Formula | C20H21N7O6 |
| Molecular Weight | 455.42400 |
| Exact Mass | 455.15500 |
| PSA | 204.75000 |
| LogP | 1.36390 |
| Index of Refraction | 1.732 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| RIDADR | NONH for all modes of transport |
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~80%
2-[[4-[(2-Amino... CAS#:2410-93-7 |
| Literature: Charlton, Peter A.; Young, Douglas W. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1982 , p. 1363 - 1370 |
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2-[[4-[(2-Amino... CAS#:2410-93-7 |
| Literature: Journal of the American Chemical Society, , vol. 70, p. 1922,1925 |
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2-[[4-[(2-Amino... CAS#:2410-93-7 |
| Literature: Journal of the American Chemical Society, , vol. 70, p. 1922,1925 |
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~%
2-[[4-[(2-Amino... CAS#:2410-93-7 |
| Literature: Journal of the American Chemical Society, , vol. 71, p. 1753,1757 |
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~%
2-[[4-[(2-Amino... CAS#:2410-93-7 |
| Literature: Journal of the American Chemical Society, , vol. 70, p. 1922,1925 |
![N-[4-(Methylamino)benzoyl]-L-glutamic Acid structure](https://image.chemsrc.com/caspic/434/52980-68-4.png)
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The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.
Lancet 2(8242) , 337-40, (1981) It is suggested that in man the methyl folate trap is a normal physiological response to impending methyl group deficiency resulting from a very low supply of methionine. This decreases cellular S-ade... |
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Enhancement of recovery from psychiatric illness by methylfolate.
Lancet 336(8712) , 392-5, (1990) 41 (33%) of 123 patients with acute psychiatric disorders (DSM III diagnosis of major depression or schizophrenia) had borderline or definite folate deficiency (red-cell folate below 200 micrograms/l)... |
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Differential effects of stimulus termination on excitation and desensitization of folic acid receptors and guanylate cyclase in Dictyostelium discoideum.
Biochim. Biophys. Acta 930(1) , 1-9, (1987) The response of guanylate cyclase to addition of extracellular stimuli is well documented. Here we report for the first time the response of guanylate cyclase to removal of stimuli. Three methods were... |
| N-[p-[[(2-AMino-4-hydroxy-6-pteridinyl)Methyl]MethylaMino]benzoyl]glutaMic Acid |
| N(10)-methylfolate |
| N-(10-methyl-pteroyl)-L-glutamic acid |
| N-[4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]MethylaMino]benzoyl]-L-glutaMic Acid |
| Methotrexate impurity C |
| 10-Methylpteroylglutamic acid |
| N10-methylfolic acid |
| N10-MethylpteroylglutaMic Acid |
| N-[p-[[(2-Amino-4-hydroxypteridin-6-yl)methyl]methylamino]benzoyl]-L-glutamic acid |
| N-[4-[[(2-Amino-4-hydroxy-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid |
| 1-methylfolic acid |
| N-(10-Methyl-pteroyl)-L-glutaminsaeure |
| 10-methylpteroylglutamlic acid |
| N-[4-[Methyl(2-amino-4-hydroxypteridine-6-ylmethyl)amino]benzoyl]glutamic acid |
| 2-[[4-[(2-Amino-4-Oxo-1H-Pteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid |