MPro Inhibitor 11b

Modify Date: 2024-01-09 08:20:22

MPro Inhibitor 11b structure	Common Name	MPro Inhibitor 11b
	CAS Number	2413716-71-7	Molecular Weight	464.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₂₅FN₄O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MPro Inhibitor 11b

SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].

Name	SARS-CoV MPro-IN-1

Description	SARS-CoV MPro-IN-1 is a SARS-CoV-2 3CLpro covalent inhibitor, with an IC50 of 40 nM. SARS-CoV MPro-IN-1 shows good anti-SARS-CoV-2-infection activity in cell culture with an EC50 of 0.33 μM. SARS-CoV MPro-IN-1 has the potential for COVID-19 research[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vivo	SARS-CoV MPro-IN-1 (compound 11b) (5 mg/kg; intravenous drip administration) shows the t1/2 is <1.65 hours and the clearance rate is 20.6 mL/min/mg[1].
References	[1]. Dai W, et al. Structure-Based Design, Synthesis and Biological Evaluation of Peptidomimetic Aldehydes as a Novel Series of Antiviral Drug Candidates Targeting the SARS-CoV-2 Main Protease. bioRxiv; 2020.

Molecular Formula	C₂₅H₂₅FN₄O₄
Molecular Weight	464.49

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MPro Inhibitor 11b
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Purity: 98.0%
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