NF-κB/MAPK-IN-1

Modify Date: 2024-04-06 18:48:20

NF-κB/MAPK-IN-1 structure	Common Name	NF-κB/MAPK-IN-1
	CAS Number	2413940-56-2	Molecular Weight	477.51
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₇NO₇	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NF-κB/MAPK-IN-1

NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].

Name	NF-κB/MAPK-IN-1

Description	NF-κB/MAPK-IN-1 (compound 11a) is a potent inhibitor of NF-κB and MAPK pathway. NF-κB/MAPK-IN-1 shows inhibitory activity against NO production, with an IC50 of 6.96 µM. NF-κB/MAPK-IN-1 suppresses LPS-induced iNOS, COX-2, ERΚ and P38 signaling activation. NF-κB/MAPK-IN-1 can prevent LPS induced inflammatory response in macrophages. NF-κB/MAPK-IN-1 can be used for rheumatoid arthritis (RA) research[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	NF-κB p38 COX-2
References	[1]. Hu YS, et al. Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. Bioorg Chem. 2020 May;98:103735.

Molecular Formula	C₂₇H₂₇NO₇
Molecular Weight	477.51

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NF-κB/MAPK-IN-1
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Purity: 98.0%
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