ALR1/2-IN-1

Modify Date: 2024-01-09 11:01:37

ALR1/2-IN-1 Structure
ALR1/2-IN-1 structure
Common Name ALR1/2-IN-1
CAS Number 2419233-57-9 Molecular Weight 434.49
Density N/A Boiling Point N/A
Molecular Formula C18H18N4O5S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of ALR1/2-IN-1


ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].

 Names

Name ALR1/2-IN-1

 ALR1/2-IN-1 Biological Activity

Description ALR1/2-IN-1 (Compound 6e) is an aldehyde reductase (ALR1) and aldose reductase (ALR2) inhibitor with IC50 values of 3.26 μM and 3.06 μM against ALR1 and ALR2, respectively. ALR1/2-IN-1 shows anticancer activity[1].
Related Catalog
Target

IC50: 3.06 μM (ALR2), 3.26 μM (ALR1)[1]

In Vitro ALR1/2-IN-1 (Compound 6e) (100 µM) shows cytotoxic potential with 32.9 ± 3.26% inhibition against cervical carcinoma cells HeLa[1].
References

[1]. Javid N, et al. Exploiting oxadiazole-sulfonamide hybrids as new structural leads to combat diabetic complications via aldose reductase inhibition. Bioorg Chem. 2020 Jun;99:103852.

 Chemical & Physical Properties

Molecular Formula C18H18N4O5S2
Molecular Weight 434.49