JKE-1674
Modify Date: 2024-01-10 14:24:06
JKE-1674 structure
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Common Name | JKE-1674 | ||
|---|---|---|---|---|
| CAS Number | 2421119-60-8 | Molecular Weight | 451.303 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 595.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C20H20Cl2N4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 313.9±32.9 °C | |
Use of JKE-1674JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor. JKE-1674 kills cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors[1]. |
| Name | JKE-1674 |
|---|---|
| Synonym | More Synonyms |
| Description | JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor. JKE-1674 kills cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors[1]. |
|---|---|
| Related Catalog | |
| Target |
GPX4[1] |
| In Vitro | JKE-1674 exhibits activity indistinguishable from that of ML210 in cellular target engagement assays including yielding the same +434Da GPX4 adduct in cells. JKE-1674 kills cells in a manner that is equipotent to ML210 and is completely rescued by ferroptosis inhibitors. JKE-1674 forms a nitrile-oxide electrophile in cells. JKE-1674 dehydration yields a nitrile-oxide electrophile that binds GPX4. JKE-1674 exhibits far greater stability than chloroacetamide inhibitors[1]. |
| In Vivo | JKE-1674 (50 mg/kg; p.o.) can be detected in the serum of mice dosed orally with the compound[1]. Animal Model: SCID mice[1] Dosage: 50 mg/kg (Pharmacokinetic Analysis) Administration: P.o. Result: Could be detected in the serum of mice dosed orally with the compound. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 595.5±60.0 °C at 760 mmHg |
| Molecular Formula | C20H20Cl2N4O4 |
| Molecular Weight | 451.303 |
| Flash Point | 313.9±32.9 °C |
| Exact Mass | 450.086151 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.651 |
| 1,2-Propanedione, 1-[4-[bis(4-chlorophenyl)methyl]-1-piperazinyl]-3-nitro-, 2-oxime, (2E)- |
| (2E)-1-{4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl}-2-(hydroxyimino)-3-nitro-1-propanone |
| JKE-1674 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: JKE-1674 (mixture of isomers)
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: JKE-1674
- Price: ￥560.0/100mg
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥1300/1 mg
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