FGFR3-IN-2

Modify Date: 2024-01-09 23:11:51

FGFR3-IN-2 Structure
FGFR3-IN-2 structure
Common Name FGFR3-IN-2
CAS Number 2428742-58-7 Molecular Weight 597.73
Density N/A Boiling Point N/A
Molecular Formula C28H39N9O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FGFR3-IN-2


FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].

 Names

Name FGFR3-IN-2

 FGFR3-IN-2 Biological Activity

Description FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor, with IC50s of 4.1 nM and 570 nM for FGFR3 and VEGFR2, respectively. FGFR3-IN-2 can be used for the research of bladder cancer[1].
Related Catalog
Target

FGFR3:4.1 nM (IC50)

VEGFR2:570 nM (IC50)

References

[1]. Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28(10):115453.

 Chemical & Physical Properties

Molecular Formula C28H39N9O4S
Molecular Weight 597.73