γ-Secretase modulator 11 hydrochloride

Modify Date: 2024-04-08 17:02:20

γ-Secretase modulator 11 hydrochloride structure	Common Name	γ-Secretase modulator 11 hydrochloride
	CAS Number	2434630-30-3	Molecular Weight	520.96
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₈H₂₃ClF₂N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of γ-Secretase modulator 11 hydrochloride

γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].

Name	γ-Secretase modulator 11 hydrochloride

Description	γ-Secretase modulator 11 hydrochloride (compound 1o) is a potent and orally active γ-secretase modulator with an IC50 of 0.029 µM. γ-Secretase modulator 11 hydrochloride induces a robust reduction in brain Aβ42 levels. γ-Secretase modulator 11 hydrochloride rescues cognitive deficits exhibited by AD model mice. γ-Secretase modulator 11 hydrochloride has the potential for the research of alzheimer's disease[1].
Related Catalog	Research Areas >> Neurological Disease
Target	IC50: 0.029 µM nM (γ-Secretase)[1]
References	[1]. Sekioka R, et al. Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer's disease model mice. Bioorg Med Chem. 2020 Jun 1;28(11):115455.

Molecular Formula	C₂₈H₂₃ClF₂N₄O₂
Molecular Weight	520.96

γ-Secretase modulator 11 hydrochloride

Use of γ-Secretase modulator 11 hydrochloride

Names

γ-Secretase modulator 11 hydrochloride Biological Activity

Chemical & Physical Properties