Drometrizole

Modify Date: 2024-01-02 12:00:04

Drometrizole Structure
Drometrizole structure
 Common Name Drometrizole
CAS Number 2440-22-4 Molecular Weight 225.24600
Density 1.38 Boiling Point 276.1ºC at 760mmHg
Molecular Formula C13H11N3O Melting Point 125.5-129.5 °C(lit.)
MSDS N/A Flash Point 133.9ºC

 Use of Drometrizole


Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies[1].

 Names

Name 2-(2H-Benzotriazol-2-yl)-p-cresol
Synonym More Synonyms

 Drometrizole Biological Activity

Description Drometrizole is a cosmetic ingredient as an ultraviolet light absorber. Drometrizole has no significant toxicity observed in acute oral, inhalation, or dermal toxicity studies[1].
Related Catalog
References

[1]. Lee JK, et al. Risk Assessment of Drometrizole, a Cosmetic Ingredient used as an Ultraviolet Light Absorber. Toxicol Res. 2019;35(2):119-129.

 Chemical & Physical Properties

Density 1.38
Boiling Point 276.1ºC at 760mmHg
Melting Point 125.5-129.5 °C(lit.)
Molecular Formula C13H11N3O
Molecular Weight 225.24600
Flash Point 133.9ºC
Exact Mass 225.09000
PSA 50.94000
LogP 2.43450
Vapour Pressure 4.81E-07mmHg at 25°C
Index of Refraction 1.765

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GO6860000
CHEMICAL NAME :
p-Cresol, 2-(2H-benzotriazol-2-yl)-
CAS REGISTRY NUMBER :
2440-22-4
LAST UPDATED :
199710
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H11-N3-O
MOLECULAR WEIGHT :
225.27
WISWESSER LINE NOTATION :
T56 BNNNJ CR BQ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,835,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 10(3),49,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9391 No. of Facilities: 2261 (estimated) No. of Industries: 23 No. of Occupations: 37 No. of Employees: 52370 (estimated) No. of Female Employees: 21694 (estimated)

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
WGK Germany 1
RTECS GO6860000
HS Code 2933990090

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

4-methyl-6-benzotriazol-2-yl-phenol
tinp
UV-P
Porex P
MFCD00022903
2-(2H-Benzo[d][1,2,3]triazol-2-yl)-4-methylphenol
2-(2-Hydroxy-5-Methylphenyl)benzotriazole
2,6-PYRIDINECARBOXALDEHYDE
Uvazol P
Ultraviolet Absorbent UV-P
TINUVIN P
ThasorbUvp
Drometrizole
Benazol II
2-(2-Benzotriazolyl)-p-cresol
2-(-Hydroxy-5-methylphenyl)benzo triazole
EINECS 219-470-5
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