Nucleocidin

Modify Date: 2024-01-06 10:52:35

Nucleocidin Structure
Nucleocidin structure
 Common Name Nucleocidin
CAS Number 24751-69-7 Molecular Weight 364.31000
Density 2.23g/cm3 Boiling Point 747.6ºC at 760mmHg
Molecular Formula C10H13FN6O6S Melting Point N/A
MSDS N/A Flash Point 405.9ºC

 Use of Nucleocidin


Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.

 Names

Name 4'-Fluoro-5'-O-sulfamoyladenosine
Synonym More Synonyms

 Nucleocidin Biological Activity

Description Nucleocidin is an antitrypanosomal antibiotic, inhibiting the transfer of labeled amino acid from S-RNA to protein.
Related Catalog
Target

Antibacterial[1].

In Vitro Although appreciable inhibition occurrs at low concentrations of nucleocidin, it is not possible to obtain complete inhibition even at 10-3 M. An appreciable lag occurrs before any inhibition by nucleocidin is detectable, and the length of this lag period varies inversely with the concentration of nucleocidin. Similar results are obtained when nucleocidin is added to the cell-free system from reticulocytes. By contrast, essentially complete inhibition is obtained at 10-3 M puromycin, and only at the lowest concentrations is any lag detectable. It seems that nucleocidin exhibits the pattern typical of many antibiotics, i.e. it inhibits incorporation at a stage subsequent to the formation of aminoacyl-S-RNA[1].
References

[1]. Florini JR, et al. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8.

 Chemical & Physical Properties

Density 2.23g/cm3
Boiling Point 747.6ºC at 760mmHg
Molecular Formula C10H13FN6O6S
Molecular Weight 364.31000
Flash Point 405.9ºC
Exact Mass 364.06000
PSA 197.08000
Vapour Pressure 1.79E-23mmHg at 25°C
Index of Refraction 1.848

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AU7400000
CHEMICAL NAME :
Adenosine, 4'-C-fluoro-, 5'-sulfamate
CAS REGISTRY NUMBER :
24751-69-7
LAST UPDATED :
199504
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H13-F-N6-O6-S
MOLECULAR WEIGHT :
364.35
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ IZ D- ET5OTJ BF B1OSZW CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 5,297,1981
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 ug/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 4,716,1956/1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal - cattle
DOSE/DURATION :
50 ug/kg
TOXIC EFFECTS :
Blood - other changes
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 4,716,1956/1957

 Synonyms

T-3018
Antibiotic T-3018
4'-Fluor-O5'-sulfamoyl-adenosin
5'-O-Sulfamoyl-4'-fluoroadenosine
4'-Fluor-5'-O-sulfamoyladenosin
nucleocidin
Sulfamic acid 4'-fluoro-5'-adenosyl ester
4'-fluoro-O5'-sulfamoyl-adenosine
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