Thalidomide-5-propargyne-NH2 hydrochloride
Modify Date: 2024-01-30 12:21:27
Thalidomide-5-propargyne-NH2 hydrochloride structure
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Common Name | Thalidomide-5-propargyne-NH2 hydrochloride | ||
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| CAS Number | 2490402-62-3 | Molecular Weight | 347.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14ClN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Thalidomide-5-propargyne-NH2 hydrochlorideThalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. |
| Name | Thalidomide-5-propargyne-NH2 hydrochloride |
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| Description | Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1]. |
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| Related Catalog | |
| Target |
Cereblon |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Molecular Formula | C16H14ClN3O4 |
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| Molecular Weight | 347.75 |
| Storage condition | 2-8°C |