2490402-62-3

2490402-62-3 structure

Name: Thalidomide-5-propargyne-NH2 hydrochloride
Chemical Name: Thalidomide-5-propargyne-NH2 hydrochloride
CAS Number: 2490402-62-3
Molecular Formula: C₁₆H₁₄ClN₃O₄
Molecular Weight: 347.75
Catalog: Signaling Pathways PROTAC Ligand for E3 Ligase
Create Date: 2022-01-11 07:09:38
Modify Date: 2024-01-30 12:21:27
Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].

Name	Thalidomide-5-propargyne-NH2 hydrochloride

Description	Thalidomide-5-propargyne-NH2 hydrochloride is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-propargyne-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> Ligand for E3 Ligase
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-994.