Polyinosinic-polycytidylic acid

Modify Date: 2024-01-02 19:47:41

Polyinosinic-polycytidylic acid Structure
Polyinosinic-polycytidylic acid structure
Common Name Polyinosinic-polycytidylic acid
CAS Number 24939-03-5 Molecular Weight 671.403
Density N/A Boiling Point 851.4ºC at 760 mmHg
Molecular Formula C19H27N7O16P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Polyinosinic-polycytidylic acid


Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Polyinosinic-polycytidylic acid presents in some viruses, and is therefore commonly used to model the actions of extracellular dsRNA.

 Names

Name poly(I:C)
Synonym More Synonyms

 Polyinosinic-polycytidylic acid Biological Activity

Description Polyinosinic-polycytidylic acid (Poly(I:C)) is a synthetic double-stranded RNA (dsRNA), which is a Toll-like receptor 3 (TLR3) agonist. Polyinosinic-polycytidylic acid presents in some viruses, and is therefore commonly used to model the actions of extracellular dsRNA.
Related Catalog
References

[1]. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001;413(6857):732-738.

[2]. Matsumoto M, Kikkawa S, Kohase M, Miyake K, Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. Biochem Biophys Res Commun. 2002;293(5):1364-1369.

 Chemical & Physical Properties

Boiling Point 851.4ºC at 760 mmHg
Molecular Formula C19H27N7O16P2
Molecular Weight 671.403
Exact Mass 671.098938
PSA 377.00000
Vapour Pressure 7.7E-31mmHg at 25°C
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TR0175000
CAS REGISTRY NUMBER :
24939-03-5
LAST UPDATED :
199106
DATA ITEMS CITED :
15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
365 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
185 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9500 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - lacrimation Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20 mg/kg
TOXIC EFFECTS :
Behavioral - excitement
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
15 mg/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - somnolence (general depressed activity) Blood - hemorrhage
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
220 ug/kg
TOXIC EFFECTS :
Vascular - other changes Blood - hemorrhage Nutritional and Gross Metabolic - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
28 mg/kg/28D-I
TOXIC EFFECTS :
Vascular - structural changes in vessels Blood - pigmented or nucleated red blood cells
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
2 mg/kg
SEX/DURATION :
female 8-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
DOSE :
50 ug/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
250 ug/kg
REFERENCE :
VVIRAT Voprosy Virusologii. Problems of Virology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1956- Volume(issue)/page/year: (5),540,1982 *** REVIEWS *** TOXICOLOGY REVIEW CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- Volume(issue)/page/year: 2,159,1973

 Safety Information

Hazard Codes Xn
WGK Germany 3
RTECS TR0175000

 Preparation

24939-03-5 preparation

 Synonyms

Polyinosinicacid-polycytidylicacid
Polyinosinic–polycytidylic acid
polyri:polyrc
polyi:c
Poly(I).Poly(C)
polycpolyi
5'-Inosinic acid homopolymer-5'-cytidylic acid homopolymer complex (1_1)
4-Amino-1-(5-O-phosphonopentofuranosyl)-2(1H)-pyrimidinone - 5'-inosinic acid (1:1)
Polyinosinic
2(1H)-Pyrimidinone, 4-amino-1-(5-O-phosphonopentofuranosyl)-, compd. with 5'-inosinic acid (1:1)
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