Poly(ethylene glycol)

Modify Date: 2024-01-02 15:09:06

Poly(ethylene glycol) Structure
Poly(ethylene glycol) structure
Common Name Poly(ethylene glycol)
CAS Number 25322-68-3 Molecular Weight 104.15
Density 1.125 Boiling Point 250ºC
Molecular Formula C5H12O2 Melting Point -65ºC
MSDS Chinese USA Flash Point 171ºC
Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger

 Use of Poly(ethylene glycol)


PEG300 is a neutral and biocompatible hydrophilic polymer.

 Names

Name poly(ethylene glycol)
Synonym More Synonyms

 Poly(ethylene glycol) Biological Activity

Description PEG300 is a neutral and biocompatible hydrophilic polymer.
Related Catalog
References

[1]. Bakar B, et al. Evaluation of the neurotoxicity of the polyethylene glycol hydrogel dural sealant. Turk Neurosurg. 2013;23(1):16-24.

 Chemical & Physical Properties

Density 1.125
Boiling Point 250ºC
Melting Point -65ºC
Molecular Formula C5H12O2
Molecular Weight 104.15
Flash Point 171ºC
Vapour density >1 (vs air)
Vapour Pressure <0.01 mm Hg ( 20 °C)
Index of Refraction 1.458-1.461
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility H2O: 50 mg/mL, clear, colorless

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TQ4025000
CHEMICAL NAME :
Polyethylene glycol #1000
CAS REGISTRY NUMBER :
25322-68-3
LAST UPDATED :
199710
DATA ITEMS CITED :
15

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1413,1986 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
32 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
15570 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 3,451,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 103,293,1951
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>20 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640) Volume(issue)/page/year: MSD-937
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
22500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 39,349,1950 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravaginal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
416 mg/kg/Y-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Reproductive - Tumorigenic effects - other reproductive system tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 15,252,1961 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - T0788 No. of Facilities: 60 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 1675 (estimated) NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80189 No. of Facilities: 34023 (estimated) No. of Industries: 237 No. of Occupations: 159 No. of Employees: 487377 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7669 No. of Facilities: 37662 (estimated) No. of Industries: 225 No. of Occupations: 183 No. of Employees: 1335913 (estimated) No. of Female Employees: 861947 (estimated)

 Safety Information

Symbol GHS06 GHS08 GHS09
GHS06, GHS08, GHS09
Signal Word Danger
Hazard Statements H302-H311-H373-H411
Precautionary Statements P273-P280-P301 + P312 + P330-P302 + P352 + P312-P391-P501
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/38
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TQ4110000
HS Code 3404900000

 Customs

HS Code 3404900000

 Articles36

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 Synonyms

EINECS 203-473-3
Polyethylene glycol 10000
Poly(ethylene oxide),approx. M.W. 900,000
Polyethylene glycol 1000
Poly(ethylene glycol),average M.W. 200
Polyethylene glycol 12000
Polyethylene glycol (PEG)
Poly(ethylene glycol)
Poly(ethylene g
Macrogol 300,PEG
MFCD00081839
Polyethylene Glycol
Poly(ethylene oxide)
PEG (Poly(ethylene glycol)
Polyethylene oxide
PEG300
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