ataciguat
Modify Date: 2024-01-08 17:50:59
ataciguat structure
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Common Name | ataciguat | ||
|---|---|---|---|---|
| CAS Number | 254877-67-3 | Molecular Weight | 576.493 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H19Cl2N3O6S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ataciguatAtaciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3]. |
| Name | ataciguat |
|---|---|
| Synonym | More Synonyms |
| Description | Ataciguat (HMR-1766) is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects[1][2][3]. |
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| Related Catalog | |
| Target |
soluble guanylate cyclase[1] |
| In Vitro | Ataciguat (1-100 μM) induces the relaxation in aortic rings or coronary rings[2]. Ataciguat (0.1-10 μM; 30 min) increases NO production in HUVEC cells[2]. Ataciguat (1 nM-100 μM) induces concentration-dependent relaxations in sphincter of Oddi (SO) rings pre-contracted by Carbachol[3]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H19Cl2N3O6S3 |
| Molecular Weight | 576.493 |
| Exact Mass | 574.981323 |
| PSA | 166.88000 |
| LogP | 6.08 |
| Index of Refraction | 1.685 |
| Storage condition | 2-8°C |
| 5-chloro-2-(5-chlorothiophene-2-sulfonylamino)-N-(4-(morpholine-4-sulfonyl)phenyl)benzamide |
| Benzamide, 5-chloro-2-[[(5-chloro-2-thienyl)sulfonyl]amino]-N-[4-(4-morpholinylsulfonyl)phenyl]- |
| 5-Chloro-2-{[(5-chloro-2-thienyl)sulfonyl]amino}-N-[4-(4-morpholinylsulfonyl)phenyl]benzamide |
| hmr 1766 |
| ataciguat |