H-Ile-Pro-Pro-OH

Modify Date: 2024-01-02 18:30:06

H-Ile-Pro-Pro-OH Structure
H-Ile-Pro-Pro-OH structure
Common Name H-Ile-Pro-Pro-OH
CAS Number 26001-32-1 Molecular Weight 325.40
Density 1.248 g/cm3 Boiling Point 572.556ºC at 760 mmHg
Molecular Formula C16H27N3O4 Melting Point N/A
MSDS N/A Flash Point 300.071ºC

 Use of H-Ile-Pro-Pro-OH


H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

 Names

Name h-ile-pro-pro-oh
Synonym More Synonyms

 H-Ile-Pro-Pro-OH Biological Activity

Description H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE)[1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].
Related Catalog
Target

IC50: 5 μM (ACE)[2]

In Vitro Vitro: Ile-Pro-Pro (IPP) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)[1].
In Vivo Vivo: Ile-Pro-Pro attenuates arterial dysfunction in L-NAME-treated rats[1] Ile-Pro-Pro (IPP) decreases blood pressure in spontaneously hypertensive rats (SHR) [1]. Ile-Pro-Pro (IPP) attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice[1].
References

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7.

[2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83.

 Chemical & Physical Properties

Density 1.248 g/cm3
Boiling Point 572.556ºC at 760 mmHg
Molecular Formula C16H27N3O4
Molecular Weight 325.40
Flash Point 300.071ºC
Exact Mass 325.20000
PSA 103.94000
LogP 1.00250

 Synonyms

isoleucyl-prolyl-proline
IPP,ACE-I Inhibitor
Ile-Pro-Pro
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