zpck

Modify Date: 2024-01-10 07:36:54

zpck Structure
zpck structure
Common Name zpck
CAS Number 26049-94-5 Molecular Weight 331.793
Density 1.2±0.1 g/cm3 Boiling Point 503.1±50.0 °C at 760 mmHg
Molecular Formula C18H18ClNO3 Melting Point 107-108ºC(lit.)
MSDS Chinese USA Flash Point 258.1±30.1 °C
Symbol GHS05
GHS05
Signal Word Danger

 Use of zpck


ZPCK is an oral active prodrug of gemcitabine that was designed for improved oral bioavailability[1].

 Names

Name benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 503.1±50.0 °C at 760 mmHg
Melting Point 107-108ºC(lit.)
Molecular Formula C18H18ClNO3
Molecular Weight 331.793
Flash Point 258.1±30.1 °C
Exact Mass 331.097534
PSA 55.40000
LogP 4.28
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.573
Storage condition -15°C

 Safety Information

Symbol GHS05
GHS05
Signal Word Danger
Hazard Statements H314
Precautionary Statements P280-P305 + P351 + P338-P310
Personal Protective Equipment Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes C
Risk Phrases R34
Safety Phrases 26-27-36/37/39-45
RIDADR UN 3261 8
WGK Germany 3
HS Code 2924299090

 Synthetic Route

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles8

More Articles
High-content positional biosensor screening assay for compounds to prevent or disrupt androgen receptor and transcriptional intermediary factor 2 protein-protein interactions.

Assay Drug Dev. Technol. 12(7) , 395-418, (2014)

The androgen receptor-transcriptional intermediary factor 2 (AR-TIF2) positional protein-protein interaction (PPI) biosensor assay described herein combines physiologically relevant cell-based assays ...

Inhibition of carboxypeptidase Y by chloromethyl ketone derivatives of benzyloxycarbonyl-L-phenylalanine.

J. Biochem. (Tokyo) 76 , 1355, (1974)

A chemical-genetic interaction map of small molecules using high-throughput imaging in cancer cells.

Mol. Syst. Biol. 11 , 846, (2015)

Small molecules often affect multiple targets, elicit off-target effects, and induce genotype-specific responses. Chemical genetics, the mapping of the genotype dependence of a small molecule's effect...

 Synonyms

(3S)-3-benzyloxycarbonylamino-1-chloro-4-phenyl-2-butanone
Carbamic acid, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester
benzyl (S)-(1-benzyl-3-chloro-2-oxopropyl)carbamate
N-Carbobenzoxy-L-phenylalanyl-chloromethyl ketone
Lopac-C-9511
N-benzyloxycarbonyl-L-phenylalanine chloromethyl ketone
MFCD00037114
N-CBZ-L-phenylalanine chloromethyl ketone
Benzyl [(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate
ZPCK
N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone
Carbamic acid, [3-chloro-2-oxo-1- (phenylmethyl)propyl]-, phenylmethyl ester, (S)-
L-Carbobenzyloxyphenylalanyl chloromethyl ketone
Carbamic acid, [3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester, (S)-
(S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic acid benzyl ester
EINECS 247-432-8
Z-L-Phe chloromethyl ketone
Benzyl [(2S)-4-chloro-3-oxo-1-phenyl-2-butanyl]carbamate
Benzyl [(1S)-1-benzyl-3-chloro-2-oxopropyl]carbamate
Z-Phe-CH2Cl
[N-(benzyloxycarbonyl)-L-phenylalanyl]methyl chloride
N-[(1S)-3-Chloro-2-Oxo-1-(Phenylmethyl)Propyl]-Carbamic Acid Phenylmethyl Ester
Z-Phe-CMK
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