N-(2-Phenylethyl)indomethacin Amide

Modify Date: 2024-01-03 18:00:23

N-(2-Phenylethyl)indomethacin Amide structure	Common Name	N-(2-Phenylethyl)indomethacin Amide
	CAS Number	261766-32-9	Molecular Weight	460.95
	Density	1.2±0.1 g/cm3	Boiling Point	640.5±55.0 °C at 760 mmHg
	Molecular Formula	C₂₇H₂₅ClN₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	341.2±31.5 °C

Use of N-(2-Phenylethyl)indomethacin Amide

LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].

Name	N-(2-Phenylethyl)indomethacin Amide
Synonym	More Synonyms

Description	LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
Target	Human COX-2:60 nM (IC50) Ovine COX-1:>66 μM (IC50)
References	[1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22. [2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122.

Density	1.2±0.1 g/cm3
Boiling Point	640.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₇H₂₅ClN₂O₃
Molecular Weight	460.95
Flash Point	341.2±31.5 °C
Exact Mass	460.155365
PSA	63.82000
LogP	4.31
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.613

Indometacin

CAS#:53-86-1

2-Phenylethanamine

CAS#:64-04-0

~44%

N-(2-Phenylethy...

CAS#:261766-32-9

Literature: Kalgutkar, Amit S.; Marnett, Alan B.; Crews, Brenda C.; Remmel, Rory P.; Marnett, Lawrence J. Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2860 - 2870

Precursor 2
CAS#:53-86-1 Indometacin CAS#:64-04-0 2-Phenylethanamine
DownStream 0

2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylethyl)acetamide

2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(2-phenylethyl)acetamide

1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-

N-(2-Phenylethyl)indomethacin Amide

Use of N-(2-Phenylethyl)indomethacin Amide

Names

N-(2-Phenylethyl)indomethacin Amide Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms