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261766-32-9

261766-32-9 structure
261766-32-9 structure
  • Name: N-(2-Phenylethyl)indomethacin Amide
  • Chemical Name: N-(2-Phenylethyl)indomethacin Amide
  • CAS Number: 261766-32-9
  • Molecular Formula: C27H25ClN2O3
  • Molecular Weight: 460.95
  • Catalog: Signaling Pathways Immunology/Inflammation COX
  • Create Date: 2018-11-28 16:49:15
  • Modify Date: 2024-01-03 18:00:23
  • LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
Name N-(2-Phenylethyl)indomethacin Amide
Synonyms 2-[1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-N-(2-phenylethyl)acetamide
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-(2-phenylethyl)acetamide
1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
Description LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1].
Related Catalog
Target

Human COX-2:60 nM (IC50)

Ovine COX-1:>66 μM (IC50)

References

[1]. Rory P Remmel, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug Metab Dispos. 2004 Jan;32(1):113-22.  

[2]. Remmel R P, et al. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites. Drug metabolism and disposition, 2004, 32(1): 113-122.

Density 1.2±0.1 g/cm3
Boiling Point 640.5±55.0 °C at 760 mmHg
Molecular Formula C27H25ClN2O3
Molecular Weight 460.95
Flash Point 341.2±31.5 °C
Exact Mass 460.155365
PSA 63.82000
LogP 4.31
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.613
Precursor  2

DownStream  0


Chemsrc provides CAS#:261766-32-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 261766-32-9 | Chemsrc address: https://www.chemsrc.com/en/baike/178836.html

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