5-HT4 antagonist 1

Modify Date: 2024-01-09 11:51:14

5-HT4 antagonist 1 structure	Common Name	5-HT4 antagonist 1
	CAS Number	261766-73-8	Molecular Weight	480.62
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₆N₄O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 5-HT4 antagonist 1

5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

Name	5-HT4 antagonist 1

Description	5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
Target	pKI: 9.6 (5-HT4 receptor)[1]
In Vitro	5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.
In Vivo	5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1].
References	[1]. Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.

Molecular Formula	C₂₃H₃₆N₄O₅S
Molecular Weight	480.62
Storage condition	2-8℃

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