261766-73-8

261766-73-8 structure
261766-73-8 structure
  • Name: 5-HT4 antagonist 1
  • Chemical Name: 5-HT4 antagonist 1
  • CAS Number: 261766-73-8
  • Molecular Formula: C23H36N4O5S
  • Molecular Weight: 480.62
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2018-01-28 23:08:11
  • Modify Date: 2024-01-09 11:51:14
  • 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.

Name 5-HT4 antagonist 1
Description 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6.
Related Catalog
Target

pKI: 9.6 (5-HT4 receptor)[1]

In Vitro 5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6.
In Vivo 5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1].
References

[1]. Clark RD, et al. Identification of a 5-HT4 receptor antagonist clinical candidate through side-chain modification. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1697-700.

Molecular Formula C23H36N4O5S
Molecular Weight 480.62
Storage condition 2-8℃