Name | 5-HT4 antagonist 1 |
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Description | 5-HT4 antagonist 1 is a 5-HT4 receptor antagonist with a pKi of 9.6. |
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Related Catalog | |
Target |
pKI: 9.6 (5-HT4 receptor)[1] |
In Vitro | 5-HT4 antagonist 1 (compound 6b) is a 5-HT4 receptor antagonist with a pKi of 9.6. |
In Vivo | 5-HT4 antagonist 1 (compound 6b) demonstrates good exposure and prolongs t1/2 in other species, including the mouse (t1/2 7 h), rat (t1/2 12 h) and mini-pig (t1/2 21 h). In Phase I clinical trial, it is found that 5-HT4 antagonist 1 has good oral bioavailability with a steady state plasma t1/2 of >100 h[1]. |
References |
Molecular Formula | C23H36N4O5S |
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Molecular Weight | 480.62 |
Storage condition | 2-8℃ |