Sorbitan, tri-(9Z)-9-octadecenoate

Modify Date: 2024-01-11 17:41:19

Sorbitan, tri-(9Z)-9-octadecenoate Structure
Sorbitan, tri-(9Z)-9-octadecenoate structure
 Common Name Sorbitan, tri-(9Z)-9-octadecenoate
CAS Number 26266-58-0 Molecular Weight 957.495
Density 1.0±0.1 g/cm3 Boiling Point 887.4±65.0 °C at 760 mmHg
Molecular Formula C60H108O8 Melting Point -14 °C
MSDS USA Flash Point 223.7±27.8 °C

 Use of Sorbitan, tri-(9Z)-9-octadecenoate


Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name sorbitan trioleate
Synonym More Synonyms

 Sorbitan, tri-(9Z)-9-octadecenoate Biological Activity

Description Sorbitan trioleate is an orally active nonionic surfactant with low toxicity (LD≥200 mg/kg). Sorbitan trioleate can be used as an excipient, such as surfactant, emulsifier, lubricant, wetting agent, dispersant, thickener, defoamer. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. YAMAMOTO H, et al. Study on subacute toxicity of intravenous sorbitan trioleate (STO) in Wistar rats[J]. The Journal of Toxicological Sciences, 1983, 8(4): 301-310.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 887.4±65.0 °C at 760 mmHg
Melting Point -14 °C
Molecular Formula C60H108O8
Molecular Weight 957.495
Flash Point 223.7±27.8 °C
Exact Mass 956.804443
PSA 108.36000
LogP 24.10
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.499

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WG2934550
CHEMICAL NAME :
Sorbitan, tris(9-octadecenoate), (Z)-
CAS REGISTRY NUMBER :
26266-58-0
LAST UPDATED :
199701
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C60-H108-O8
MOLECULAR WEIGHT :
957.68

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 4(3),65,1985 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7 gm/kg/35D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells Blood - changes in spleen Blood - changes in erythrocyte (RBC) count
REFERENCE :
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 8,301,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82920 No. of Facilities: 416 (estimated) No. of Industries: 16 No. of Occupations: 25 No. of Employees: 19949 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82920 No. of Facilities: 1632 (estimated) No. of Industries: 17 No. of Occupations: 21 No. of Employees: 25056 (estimated) No. of Female Employees: 5808 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi
Risk Phrases R38
Safety Phrases S26
RIDADR NONH for all modes of transport
WGK Germany 1
RTECS WG2934550
HS Code 2932190090

 Customs

HS Code 2932190090
Summary 2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

 Articles28

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A microcalorimetric investigation of the interaction of surfactants with crystalline and partially crystalline salbutamol sulphate in a model inhalation aerosol system.

Pharm. Res. 12(11) , 1689-93, (1995)

The purpose of the work is to study the adsorption of Oleic acid and Span 85 (materials frequently used in aerosols as surfactants) onto partially amorphous and essentially crystalline salbutamol sulp...

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J. Anim. Sci. 87(3) , 1085-96, (2009)

The effects of 3 nonionic surfactants (NIS), including alkyl polyglucoside (APG), sorbitan trioleate (Span85), and polyoxyethylene sorbitan monostearate (Tween80), on in vitro fermentation characteris...

 Synonyms

1,4-anhydro-2,3,6-tri-O--(9Z)-octadec-9-enoyl-D-glucitol
emsorb2503
te33
SPAN NO 85
EINECS 247-569-3
Sorbitane trioleate
Sorbitan, tri-(9Z)-9-octadecenoate
1,4-anhydro-2,3,6-tri-O--(9Z)-octadec-9-enoyl-L-iditol
ionets85
SPAN 85
(Sorbitan Trioleate)
L-iditol, 1,4-anhydro-2,3,6-tris-O-[(9Z)-1-oxo-9-octadecenyl]-
SPAN(R) 85
L-Iditol, 1,4-anhydro-2,3,6-tris-O-[(9Z)-1-oxo-9-octadecen-1-yl]-
MFCD00133820
op85r
glycomulto
crill5
1,4-Anhydro-2,3,6-tri-O--(9Z)-9-octadecenoyl-L-iditol
emasol430
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