15-keto Prostaglandin E2

Modify Date: 2024-01-11 09:39:34

15-keto Prostaglandin E2 structure	Common Name	15-keto Prostaglandin E2
	CAS Number	26441-05-4	Molecular Weight	350.45
	Density	1.1±0.1 g/cm3	Boiling Point	534.4±50.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₃₀O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	291.1±26.6 °C

Use of 15-keto Prostaglandin E2

15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].

Name	15-dehydro-prostaglandin E2
Synonym	More Synonyms

Description	15-keto-Prostaglandin E2 is an endogenous metabolite. 15-keto-Prostaglandin E2 inhibits STAT3 activation by binding to its Cys259 residue. 15-keto-Prostaglandin E2 can bind and stabilize EP2 and EP4 receptor. 15-keto-Prostaglandin E2 inhibits breast cancer cell growth and progression. 15-keto-Prostaglandin E2 activates PPAR-γ and promotes fungal growth[1][2][3].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR
References	[1]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175. [2]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022 Dec 1;310:121114. [3]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019 Mar 28;15(3):e1007597.

Description

Related Catalog

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor

Signaling Pathways >> Cell Cycle/DNA Damage >> PPAR

References

[1]. Lee EJ, et al. 15-Keto prostaglandin E2 suppresses STAT3 signaling and inhibits breast cancer cell growth and progression. Redox Biol. 2019 May;23:101175.

[2]. Kourpa A, et al. 15-keto-Prostaglandin E2 exhibits bioactive role by modulating glomerular cytoarchitecture through EP2/EP4 receptors. Life Sci. 2022 Dec 1;310:121114.

[3]. Evans RJ, et al. 15-keto-prostaglandin E2 activates host peroxisome proliferator-activated receptor gamma (PPAR-γ) to promote Cryptococcus neoformans growth during infection. PLoS Pathog. 2019 Mar 28;15(3):e1007597.

Density	1.1±0.1 g/cm3
Boiling Point	534.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₃₀O₅
Molecular Weight	350.45
Flash Point	291.1±26.6 °C
Exact Mass	350.209320
PSA	91.67000
LogP	1.74
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.552