sorbitan tristearate structure
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Common Name | sorbitan tristearate | ||
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CAS Number | 26658-19-5 | Molecular Weight | 963.54200 | |
Density | 0.96 g/cm3 | Boiling Point | 885.4ºC at 760 mmHg | |
Molecular Formula | C60H114O8 | Melting Point | N/A | |
MSDS | USA | Flash Point | 150 °C |
Use of sorbitan tristearateSorbitan tristearate is a non-ionic surfactant, with a synergistic effect on skin permeability. Sorbitan tristearate can be used as an excipient, such as emulsifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
Name | sorbitan tristearate |
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Synonym | More Synonyms |
Description | Sorbitan tristearate is a non-ionic surfactant, with a synergistic effect on skin permeability. Sorbitan tristearate can be used as an excipient, such as emulsifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2]. |
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Related Catalog | |
References |
Density | 0.96 g/cm3 |
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Boiling Point | 885.4ºC at 760 mmHg |
Molecular Formula | C60H114O8 |
Molecular Weight | 963.54200 |
Flash Point | 150 °C |
Exact Mass | 962.85100 |
PSA | 108.36000 |
LogP | 17.89740 |
Vapour Pressure | 0mmHg at 25°C |
Index of Refraction | 1.478 |
Section 1. Chemical Product and Company Identification Sorbitan tristearate Common Name/ Trade Name Manufacturer Commercial Name(s) Synonym
Chemical Name Chemical Family Sorbitan tristearate Section 4. First Aid Measures Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Get medical attention if irritation occurs. Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation develops. Serious Skin ContactNot available. InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention. Serious InhalationNot available. IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen tight clothing such as a collar, tie, belt or waistband. Serious IngestionNot available. Section 5. Fire and Explosion Data Flammability of the Product May be combustible at high temperature. Auto-Ignition Temperature Not available. Flash PointsCLOSED CUP: 150°C (302°F). Flammable LimitsNot available. Products of CombustionNot available. Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat. Various Substances Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available. of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available. Fire Fighting MediaSMALL FIRE: Use DRY chemical powder. and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet. Special Remarks onNot available. Fire Hazards Special Remarks on Explosion Not available. Hazards Section 6. Accidental Release Measures Small SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal. Large SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by spreading water on the contaminated surface and allow to evacuate through the sanitary system. Section 7. Handling and Storage PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not breathe gas/fumes/ vapor/spray. Keep container tightly closed. Keep container in a cool, well-ventilated area. Storage Sorbitan tristearate Section 8. Exposure Controls/Personal Protection Engineering ControlsProvide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the work-station location. Personal ProtectionSafety glasses. Synthetic apron. Gloves (impervious). Respiratory protection is not necessary for normal handling. Good room ventilation or use of local exhaust (fume hood) is sufficient. Use a vapor respirator under conditions where exposure to the substance is apparent (e.g. generation of high concentrations of mist or vapor, inadequate ventilation, development of respiratory tract irritation), and engineering controls are not feasible. Be sure to use an approved/certified respirator or equivalent. Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a a Large Spillspecialist BEFORE handling this product. Exposure LimitsNot available. Section 9. Physical and Chemical Properties Physical state and appearance Liquid.OdorNot available. TasteNot available. Molecular WeightNot available. Not available. Color pH (1% soln/water)Not applicable. Boiling PointNot available. Decomposes. Melting Point Critical TemperatureNot available. 0.95-0.98 (Water = 1) Specific Gravity Vapor PressureNot available. Vapor DensityNot available. VolatilityNot available. Odor ThresholdNot available. Not available. Water/Oil Dist. Coeff. Ionicity (in Water)Not available. Dispersion PropertiesNot available. SolubilityInsoluble in cold water. Section 10. Stability and Reactivity Data StabilityThe product is stable. Not available. Instability Temperature Conditions of InstabilityExcess heat, incompatible materials Incompatibility with variousReactive with oxidizing agents. substances CorrosivityNon-corrosive in presence of glass. Not available. Special Remarks on Reactivity Special Remarks onNot available. Corrosivity PolymerizationWill not occur. Sorbitan tristearate Section 11. Toxicological Information Routes of EntryInhalation. Ingestion. Toxicity to AnimalsLD50: Not available. LC50: Not available. Chronic Effects on Humans Not available. Other Toxic Effects on Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation. Humans Special Remarks onNot available. Toxicity to Animals Special Remarks onNot available. Chronic Effects on Humans Special Remarks on otherAcute Potential Health Effects: Toxic Effects on HumansSkin: May cause skin irritation. Eyes: May cause eye irritation. Inhalation: May cause respiratory tract irritation. Ingestion: May cause digestive tract irritation. Section 12. Ecological Information EcotoxicityNot available. BOD5 and CODNot available. Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products may arise. Toxicity of the ProductsNot available. of Biodegradation Special Remarks on theNot available. Products of Biodegradation Section 13. Disposal Considerations Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental control regulations. Section 14. Transport Information DOT ClassificationNot a DOT controlled material (United States). Not applicable. Identification Special Provisions forNot applicable. Transport DOT (Pictograms) Sorbitan tristearate Section 15. Other Regulatory Information and Pictograms TSCA 8(b) inventory: Sorbitan tristearate Federal and State Regulations CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has Proposition 65found to cause cancer which would require a warning under the statute: No products were found. Warnings California prop. 65: This product contains the following ingredients for which the State of California has found to cause birth defects which would require a warning under the statute: No products were found. Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS No. 247-891-4). Canada: Listed on Canadian Domestic Substance List (DSL). China: Listed on National Inventory. Japan: Listed on National Inventory (ENCS). Korea: Listed on National Inventory (KECI). Philippines: Listed on National Inventory (PICCS). Australia: Listed on AICS. Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada). DSCL (EEC)This product is not classifiedNot applicable. according to the EU regulations. Health Hazard HMIS (U.S.A.)2 National Fire Protection 1 Flammability 1 Association (U.S.A.) Fire Hazard 1 0 Reactivity Health Reactivity 1 Specific hazard Personal Protection a WHMIS (Canada) (Pictograms) DSCL (Europe) (Pictograms) TDG (Canada) (Pictograms) ADR (Europe) (Pictograms) Protective Equipment Gloves (impervious). Lab coat. Not applicable. Safety glasses. SECTION 16 - ADDITIONAL INFORMATION N/A |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
Glycomul(R) TS KFG |
SPAN 65 |
EmulsifierS65 |
SPAN(R) 65 |
SPAN(TM) 65 |
Lonzest(R) STS |
Sorbitantristearat |
EMALEX EG-2854-S |
MFCD00151165 |
EINECS 247-891-4 |