sorbitan tristearate

Modify Date: 2024-01-05 17:05:33

sorbitan tristearate Structure
sorbitan tristearate structure
Common Name sorbitan tristearate
CAS Number 26658-19-5 Molecular Weight 963.54200
Density 0.96 g/cm3 Boiling Point 885.4ºC at 760 mmHg
Molecular Formula C60H114O8 Melting Point N/A
MSDS USA Flash Point 150 °C

 Use of sorbitan tristearate


Sorbitan tristearate is a non-ionic surfactant, with a synergistic effect on skin permeability. Sorbitan tristearate can be used as an excipient, such as emulsifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name sorbitan tristearate
Synonym More Synonyms

 sorbitan tristearate Biological Activity

Description Sorbitan tristearate is a non-ionic surfactant, with a synergistic effect on skin permeability. Sorbitan tristearate can be used as an excipient, such as emulsifier. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Karande P, et al. Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate[J]. European journal of pharmaceutical sciences, 2007, 31(1): 1-7.

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 0.96 g/cm3
Boiling Point 885.4ºC at 760 mmHg
Molecular Formula C60H114O8
Molecular Weight 963.54200
Flash Point 150 °C
Exact Mass 962.85100
PSA 108.36000
LogP 17.89740
Vapour Pressure 0mmHg at 25°C
Index of Refraction 1.478

 MSDS


Section 1. Chemical Product and Company Identification
Sorbitan tristearate
Common Name/
Trade Name
Manufacturer
Commercial Name(s)
Synonym
Chemical Name
Chemical Family
Sorbitan tristearate

Section 4. First Aid Measures
Eye ContactCheck for and remove any contact lenses. In case of contact, immediately flush eyes with plenty of water for
at least 15 minutes. Get medical attention if irritation occurs.
Skin ContactWash with soap and water. Cover the irritated skin with an emollient. Get medical attention if irritation
develops.
Serious Skin ContactNot available.
InhalationIf inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen.
Get medical attention.
Serious InhalationNot available.
IngestionDo NOT induce vomiting unless directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. If large quantities of this material are swallowed, call a physician immediately. Loosen
tight clothing such as a collar, tie, belt or waistband.
Serious IngestionNot available.

Section 5. Fire and Explosion Data
Flammability of the Product May be combustible at high temperature.
Auto-Ignition Temperature Not available.
Flash PointsCLOSED CUP: 150°C (302°F).
Flammable LimitsNot available.
Products of CombustionNot available.
Fire Hazards in Presence of Slightly flammable to flammable in presence of open flames and sparks, of heat.
Various Substances
Explosion Hazards in Presence Risks of explosion of the product in presence of mechanical impact: Not available.
of Various SubstancesRisks of explosion of the product in presence of static discharge: Not available.
Fire Fighting MediaSMALL FIRE: Use DRY chemical powder.
and InstructionsLARGE FIRE: Use water spray, fog or foam. Do not use water jet.
Special Remarks onNot available.
Fire Hazards
Special Remarks on Explosion Not available.
Hazards

Section 6. Accidental Release Measures
Small SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal.
Large SpillAbsorb with an inert material and put the spilled material in an appropriate waste disposal. Finish cleaning by
spreading water on the contaminated surface and allow to evacuate through the sanitary system.

Section 7. Handling and Storage
PrecautionsKeep away from heat. Keep away from sources of ignition. Ground all equipment containing material. Do not
breathe gas/fumes/ vapor/spray.
Keep container tightly closed. Keep container in a cool, well-ventilated area.
Storage
Sorbitan tristearate

Section 8. Exposure Controls/Personal Protection
Engineering ControlsProvide exhaust ventilation or other engineering controls to keep the airborne concentrations of vapors below
their respective threshold limit value. Ensure that eyewash stations and safety showers are proximal to the
work-station location.
Personal ProtectionSafety glasses. Synthetic apron. Gloves (impervious). Respiratory protection is not necessary for normal
handling. Good room ventilation or use of local exhaust (fume hood) is sufficient. Use a vapor respirator
under conditions where exposure to the substance is apparent (e.g. generation of high concentrations of mist
or vapor, inadequate ventilation, development of respiratory tract irritation), and engineering controls are not
feasible. Be sure to use an approved/certified respirator or equivalent.
Personal Protection in Case of Splash goggles. Full suit. Boots. Gloves. Suggested protective clothing might not be sufficient; consult a
a Large Spillspecialist BEFORE handling this product.
Exposure LimitsNot available.

Section 9. Physical and Chemical Properties
Physical state and appearance Liquid.OdorNot available.
TasteNot available.
Molecular WeightNot available.
Not available.
Color
pH (1% soln/water)Not applicable.
Boiling PointNot available.
Decomposes.
Melting Point
Critical TemperatureNot available.
0.95-0.98 (Water = 1)
Specific Gravity
Vapor PressureNot available.
Vapor DensityNot available.
VolatilityNot available.
Odor ThresholdNot available.
Not available.
Water/Oil Dist. Coeff.
Ionicity (in Water)Not available.
Dispersion PropertiesNot available.
SolubilityInsoluble in cold water.

Section 10. Stability and Reactivity Data
StabilityThe product is stable.
Not available.
Instability Temperature
Conditions of InstabilityExcess heat, incompatible materials
Incompatibility with variousReactive with oxidizing agents.
substances
CorrosivityNon-corrosive in presence of glass.
Not available.
Special Remarks on
Reactivity
Special Remarks onNot available.
Corrosivity
PolymerizationWill not occur.
Sorbitan tristearate

Section 11. Toxicological Information
Routes of EntryInhalation. Ingestion.
Toxicity to AnimalsLD50: Not available.
LC50: Not available.
Chronic Effects on Humans Not available.
Other Toxic Effects on
Slightly hazardous in case of skin contact (irritant), of ingestion, of inhalation.
Humans
Special Remarks onNot available.
Toxicity to Animals
Special Remarks onNot available.
Chronic Effects on Humans
Special Remarks on otherAcute Potential Health Effects:
Toxic Effects on HumansSkin: May cause skin irritation.
Eyes: May cause eye irritation.
Inhalation: May cause respiratory tract irritation.
Ingestion: May cause digestive tract irritation.

Section 12. Ecological Information
EcotoxicityNot available.
BOD5 and CODNot available.
Products of BiodegradationPossibly hazardous short term degradation products are not likely. However, long term degradation products
may arise.
Toxicity of the ProductsNot available.
of Biodegradation
Special Remarks on theNot available.
Products of Biodegradation

Section 13. Disposal Considerations
Waste DisposalWaste must be disposed of in accordance with federal, state and local environmental
control regulations.

Section 14. Transport Information
DOT ClassificationNot a DOT controlled material (United States).
Not applicable.
Identification
Special Provisions forNot applicable.
Transport
DOT (Pictograms)
Sorbitan tristearate

Section 15. Other Regulatory Information and Pictograms
TSCA 8(b) inventory: Sorbitan tristearate
Federal and State
Regulations
CaliforniaCalifornia prop. 65: This product contains the following ingredients for which the State of California has
Proposition 65found to cause cancer which would require a warning under the statute: No products were found.
Warnings
California prop. 65: This product contains the following ingredients for which the State of California has
found to cause birth defects which would require a warning under the statute: No products were found.
Other RegulationsEINECS: This product is on the European Inventory of Existing Commercial Chemical Substances (EINECS
No. 247-891-4).
Canada: Listed on Canadian Domestic Substance List (DSL).
China: Listed on National Inventory.
Japan: Listed on National Inventory (ENCS).
Korea: Listed on National Inventory (KECI).
Philippines: Listed on National Inventory (PICCS).
Australia: Listed on AICS.
Other ClassificationsWHMIS (Canada) Not controlled under WHMIS (Canada).
DSCL (EEC)This product is not classifiedNot applicable.
according to the EU regulations.
Health Hazard
HMIS (U.S.A.)2 National Fire Protection
1 Flammability
1 Association (U.S.A.)
Fire Hazard
1 0 Reactivity
Health
Reactivity
1
Specific hazard
Personal Protection
a
WHMIS (Canada)
(Pictograms)
DSCL (Europe)
(Pictograms)
TDG (Canada)
(Pictograms)
ADR (Europe)
(Pictograms)
Protective Equipment
Gloves (impervious).
Lab coat.
Not applicable.
Safety glasses.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 1

 Synonyms

Glycomul(R) TS KFG
SPAN 65
EmulsifierS65
SPAN(R) 65
SPAN(TM) 65
Lonzest(R) STS
Sorbitantristearat
EMALEX EG-2854-S
MFCD00151165
EINECS 247-891-4
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