STAT3-IN-18

Modify Date: 2024-07-19 13:52:29

STAT3-IN-18 structure	Common Name	STAT3-IN-18
	CAS Number	2668267-41-0	Molecular Weight	630.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₄Cl₂N₂O₆Pt	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of STAT3-IN-18

STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.

Name	STAT3-IN-18

Description	STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> JAK Signaling Pathways >> Epigenetics >> JAK Signaling Pathways >> Stem Cell/Wnt >> JAK Signaling Pathways >> JAK/STAT Signaling >> STAT Signaling Pathways >> Immunology/Inflammation >> COX
References	[1]. Cai L, Wang Y, Chen H, Tan Y, Yang T, Zhang S, Guo Z, Wang X. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11351-11364.

Molecular Formula	C₁₈H₂₄Cl₂N₂O₆Pt
Molecular Weight	630.38

STAT3-IN-18

Use of STAT3-IN-18

Names

STAT3-IN-18 Biological Activity

Chemical & Physical Properties