Etravirine (TMC125)

Modify Date: 2024-01-03 08:11:25

Etravirine (TMC125) structure	Common Name	Etravirine (TMC125)
	CAS Number	269055-15-4	Molecular Weight	435.277
	Density	1.6±0.1 g/cm3	Boiling Point	637.4±65.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₅BrN₆O	Melting Point	265ºC (dec.)
	MSDS	N/A	Flash Point	339.3±34.3 °C

Use of Etravirine (TMC125)

Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.

Name	etravirine
Synonym	More Synonyms

Description	Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection
In Vitro	TMC125 is highly active against wild-type HIV-1 (50% effective concentration [EC50]=1.4 to 4.8 nM) and shows some activity against HIV-2 (EC50=3.5 μM). TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. TMC125 has activity for 19 viruses with EC50 of < 5 nM[1].
In Vivo	Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group[2].
References	[1]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [2]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

Density	1.6±0.1 g/cm3
Boiling Point	637.4±65.0 °C at 760 mmHg
Melting Point	265ºC (dec.)
Molecular Formula	C₂₀H₁₅BrN₆O
Molecular Weight	435.277
Flash Point	339.3±34.3 °C
Exact Mass	434.049072
PSA	120.64000
LogP	4.19
Vapour Pressure	0.0±1.9 mmHg at 25°C
Index of Refraction	1.703
Storage condition	-20°C Freezer

Hazard Codes	Xi

Benzonitrile, 4-[[6-amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl]oxy]-3,5-dimethyl-

etravirine

4-({6-Amino-5-bromo-2-[(4-cyanophenyl)amino]-4-pyrimidinyl}oxy)-3,5-dimethylbenzonitrile

tmc 125

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Etravirine (TMC125)
Price: Click To Check
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Etravirine (TMC125)
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DC Chemicals Limited
China
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Etravirine
Price: ￥Inquiry/1g
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: etravirine
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Delivery: Inquiry
Contact: Anson
Email: info@tianfuchem.com

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Price: $166/10mM*1mLinDMSO

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