Etravirine-d6

Modify Date: 2024-01-14 17:55:14

Etravirine-d6 structure	Common Name	Etravirine-d6
	CAS Number	1142096-06-7	Molecular Weight	443.32600
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₇BrD₈N₆O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Etravirine-d6

Etravirine-d8 (R165335-d8) is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV[1][2].

Name	4-[6-amino-5-bromo-2-(4-cyanoanilino)pyrimidin-4-yl]oxy-2,6-dideuterio-3,5-bis(trideuteriomethyl)benzonitrile
Synonym	More Synonyms

Description	Etravirine-d8 (R165335-d8) is the deuterium labeled Etravirine. Etravirine (R165335) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) used for the treatment of HIV[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection Signaling Pathways >> Anti-infection >> Reverse Transcriptase
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Andries, K., et al. TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. Antimicrob Agents Chemother, 2004. 48(12): p. 468 [3]. Lazzarin, A., et al. Efficacy and safety of TMC125 (etravirine) in treatment-experienced HIV-1-infected patients in DUET-2: 24-week results from a randomised, double-blind, placebo-controlled trial. Lancet, 2007. 370(9581): p. 39-48.

Molecular Formula	C₂₀H₇BrD₈N₆O
Molecular Weight	443.32600
Exact Mass	442.09900
PSA	120.64000
LogP	5.37156

Precursor 5
CAS#:1316315-43-1 4-(5-bromo-6-ch... CAS#:1316315-41-9 4-bromo-2,6-[(2... CAS#:1316315-38-4 1-(methoxymetho... CAS#:824-91-9 methoxymethoxyb...
CAS#:108-95-2 Phenol
DownStream 0

Etravirine-d8

TMC 125-d8

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Etravirine-d6
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

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