Influenza virus-IN-7

Modify Date: 2024-01-04 09:33:30

Influenza virus-IN-7 structure	Common Name	Influenza virus-IN-7
	CAS Number	2703046-92-6	Molecular Weight	612.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₆F₂N₄O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Influenza virus-IN-7

Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases[1].

Name	Influenza virus-IN-7

Description	Influenza virus-IN-7 (Example 16) is an orally active cap-dependent endonuclease inhibitor that can be used for the research of influenza viral infectious diseases[1].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
Target	IC50: Cap-dependent endonuclease[1]
In Vitro	Influenza virus-IN-7 (Example 16) 在 MDCK 细胞中显示出对流感 A/Weiss/43(H1N1) 病毒的抗病毒活性，EC50 为 <5 nM (CC50 >1000 nM)[1]。
In Vivo	Influenza virus-IN-7 (Example 16; 5 mg/kg; i.g.; twice daily for 5 days) 可提高 WSN/33 (H1N1) 感染小鼠模型的存活率[1]。 Animal Model: WSN/33 (H1N1) infection mouse model[1] Dosage: 5 mg/kg Administration: Intragastric administration, twice daily for 5 days Result: Significantly improved the survival rate.
References	[1]. Wang Shen, et al. Polycyclic pyridopyridazine amide oxime-containing carbocyclic derivatives and uses thereof. Patent CN114315827A.

Molecular Formula	C₂₉H₂₆F₂N₄O₇S
Molecular Weight	612.60