8RK59

Modify Date: 2024-04-06 11:18:35

8RK59 structure	Common Name	8RK59
	CAS Number	2705841-53-6	Molecular Weight	688.60
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₃₉BF₂N₁₀O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 8RK59

8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].

Name	8RK59

Description	8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase
Target	UCHL1 (ubiquitin C-terminal hydrolase L1)[1]
In Vitro	8RK59 (5 μM, 24 h) 仅与野生型 UCHL1 结合，但不与催化失活的 UCHL1 结合，表明探针结合位点是活性位点半胱氨酸[1]。
References	[1]. Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841.

Molecular Formula	C₃₃H₃₉BF₂N₁₀O₂S
Molecular Weight	688.60

8RK59

Use of 8RK59

Names

8RK59 Biological Activity

Chemical & Physical Properties