1H-Indazole

Modify Date: 2024-01-02 08:04:12

1H-Indazole Structure
1H-Indazole structure
 Common Name 1H-Indazole
CAS Number 271-44-3 Molecular Weight 118.136
Density 1.2±0.1 g/cm3 Boiling Point 270.0±9.0 °C at 760 mmHg
Molecular Formula C7H6N2 Melting Point 145-148 °C(lit.)
MSDS N/A Flash Point 128.5±11.7 °C

 Use of 1H-Indazole


Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

 Names

Name 1H-indazole
Synonym More Synonyms

 1H-Indazole Biological Activity

Description Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].
Related Catalog
In Vitro Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents[1]. Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)[2]. Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders[4].
References

[1]. Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21(5):363-376.

[2]. Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22(14):1136-1151.

[3]. Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22(14):1177-1188.

[4]. Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22(14):1189-1214.

[5]. Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21(7):839-860.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 270.0±9.0 °C at 760 mmHg
Melting Point 145-148 °C(lit.)
Molecular Formula C7H6N2
Molecular Weight 118.136
Flash Point 128.5±11.7 °C
Exact Mass 118.053101
PSA 28.68000
LogP 1.82
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.697
Water Solubility SOLUBLE IN HOT WATER

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NK7745000
CHEMICAL NAME :
1H-Indazole
CAS REGISTRY NUMBER :
271-44-3
LAST UPDATED :
199501
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C7-H6-N2
MOLECULAR WEIGHT :
118.15
WISWESSER LINE NOTATION :
T56 BMNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
440 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

 Safety Information

Hazard Codes Xi
Safety Phrases S22-S24/25
WGK Germany 3
RTECS NK7745000
HS Code 29339990

 Synthetic Route

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

isoindazole
Indazole
1H-Indazole
indazole-
MFCD00005691
EINECS 205-978-4
1,2-Benzopyrazole
1h-indazol
1,2-Benzodiazole
BENZOPYRAZOLE
Indazol
2-Azaindole
benzodiazole
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Chemsrc provides 1H-Indazole(CAS#:271-44-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of 1H-Indazole are included as well.>> amp version: 1H-Indazole

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