Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 1H-Indazole
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 1H-Indazole
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DC Chemicals Limited
China
Product Name: Indazole
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Indazole
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: Indazole
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271-44-3

271-44-3 structure

Name: 1H-Indazole
Chemical Name: 1H-indazole
CAS Number: 271-44-3
Molecular Formula: C₇H₆N₂
Molecular Weight: 118.136
Catalog: Signaling Pathways Autophagy LRRK2
Create Date: 2018-04-17 08:00:00
Modify Date: 2024-01-02 08:04:12
Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].

Name	1H-indazole
Synonyms	isoindazole Indazole 1H-Indazole indazole- MFCD00005691 EINECS 205-978-4 1,2-Benzopyrazole 1h-indazol 1,2-Benzodiazole BENZOPYRAZOLE Indazol 2-Azaindole benzodiazole

Description	Indazole, also called isoindazole, a heterocyclic aromatic organic compound. Its derivatives display a broad variety of biological activities including anti-inflammatory, antibacterial, anti-HIV, antiarrhythmic, antifungal and antitumour properties. Indazole and its derivatives can be used for research of cancer, neurological disorders, cardiovascular diseases, gastrointestinal diseases[1][2][3][4][5].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Research Areas >> Cardiovascular Disease Signaling Pathways >> Autophagy >> LRRK2 Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
In Vitro	Indazole compounds possess potential anticancer activity, and indazole-based agents such as, Axitinib (HY-10065), Lonidamine (HY-B0486) and Pazopanib (HY-10208) have already been used for cancer research, demonstrating indazole compounds as useful templates for the development of novel anticancer agents[1]. Indazoles show potent activities against neurological disorders by inhibiting the monoamine oxidase (MAO) and kinase enzymes like Glycogen synthase kinase 3 (GSK3), and leucinerich repeat kinase enzyme 2 (LRRK2)[2]. Various natural and synthetic indazole derivatives Nigellicine, Nigellamine, Nigellidine, Zanubrutinib (HY-101474A) and SCH772984 (HY-50846) showes prominent results to cure various gastrointestinal disorders[4].
References	[1]. Shang C, et al. The Anticancer Activity of Indazole Compounds: A Mini Review. Curr Top Med Chem. 2021;21(5):363-376. [2]. Pal D, et al. Importance of Indazole against Neurological Disorders. Curr Top Med Chem. 2022;22(14):1136-1151. [3]. Uppulapu SK, et al. Indazole and its Derivatives in Cardiovascular Diseases: Overview, Current Scenario, and Future Perspectives. Curr Top Med Chem. 2022;22(14):1177-1188. [4]. Saha S, et al. Indazole Derivatives Effective against Gastrointestinal Diseases. Curr Top Med Chem. 2022;22(14):1189-1214. [5]. Qin J, et al. Indazole as a Privileged Scaffold: The Derivatives and their Therapeutic Applications. Anticancer Agents Med Chem. 2021;21(7):839-860.

Density	1.2±0.1 g/cm3
Boiling Point	270.0±9.0 °C at 760 mmHg
Melting Point	145-148 °C(lit.)
Molecular Formula	C₇H₆N₂
Molecular Weight	118.136
Flash Point	128.5±11.7 °C
Exact Mass	118.053101
PSA	28.68000
LogP	1.82
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.697
Water Solubility	SOLUBLE IN HOT WATER

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7745000

CHEMICAL NAME :: 1H-Indazole

CAS REGISTRY NUMBER :: 271-44-3

LAST UPDATED :: 199501

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H6-N2

MOLECULAR WEIGHT :: 118.15

WISWESSER LINE NOTATION :: T56 BMNJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 6,480,1963

Hazard Codes	Xi
Safety Phrases	S22-S24/25
WGK Germany	3
RTECS	NK7745000
HS Code	29339990

Precursor 10
89-98-5 73183-34-3 186407-74-9 88284-48-4
18107-18-1 75307-67-4 446-52-6 1437769-72-6
679794-95-7 4403-69-4
DownStream 10
326474-67-3 32829-25-7 3176-66-7 33334-08-6
33334-11-1 36760-20-0 29110-74-5 142801-06-7
40598-94-5 40598-76-3

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

271-44-3	271-38-5
569339-86-2	4498-71-9
50264-88-5	256228-64-5
13436-48-1	98549-93-0
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1158522-08-7	940364-43-2
134104-43-1	131615-57-1
6906-52-1	930439-75-1
1018584-77-4	1375289-11-4
1463457-51-3	849349-65-1