H-L-Phe(4-NH-Poc)-OH hydrochloride

Modify Date: 2024-04-03 12:01:57

H-L-Phe(4-NH-Poc)-OH hydrochloride structure	Common Name	H-L-Phe(4-NH-Poc)-OH hydrochloride
	CAS Number	2737202-66-1	Molecular Weight	298.72
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃H₁₅ClN₂O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of H-L-Phe(4-NH-Poc)-OH hydrochloride

H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported[1][2].

Name	H-L-Phe(4-NH-Poc)-OH hydrochloride

Description	H-L-Phe(4-NH-Poc)-OH (hydrochloride) is a click chemistry reagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Le Chevalier Isaad A, et al. Side chain-to-side chain cyclization by click reaction. J Pept Sci. 2009 Jul;15(7):451-4. [2]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.

Description

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Le Chevalier Isaad A, et al. Side chain-to-side chain cyclization by click reaction. J Pept Sci. 2009 Jul;15(7):451-4.

[2]. Jiang X, et al. Recent applications of click chemistry in drug discovery. Expert Opin Drug Discov. 2019 Aug;14(8):779-789.

Molecular Formula	C₁₃H₁₅ClN₂O₄
Molecular Weight	298.72

H-L-Phe(4-NH-Poc)-OH hydrochloride

Use of H-L-Phe(4-NH-Poc)-OH hydrochloride

Names

H-L-Phe(4-NH-Poc)-OH hydrochloride Biological Activity

Chemical & Physical Properties