4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo-

Modify Date: 2024-01-30 18:07:00

4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo- Structure
4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo- structure
Common Name 4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo-
CAS Number 27430-18-8 Molecular Weight 222.22
Density 1.54g/cm3 Boiling Point N/A
Molecular Formula C9H6N2O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo-


CD00509 is a Tdp1 inhibitor, with an IC50 value of 0.71 μM. CD00509 can sensitize breast cancer cells to Camptothecin (HY-16560). CD00509 has anti-tumor activity[1].

 Names

Name 5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-diazinane-4,6-dione
Synonym More Synonyms

  Biological Activity

Description CD00509 is a Tdp1 inhibitor, with an IC50 value of 0.71 μM. CD00509 can sensitize breast cancer cells to Camptothecin (HY-16560). CD00509 has anti-tumor activity[1].
Related Catalog
References

[1]. Laev SS, et al. Tyrosyl-DNA phosphodiesterase inhibitors: Progress and potential. Bioorg Med Chem. 2016 Nov 1;24(21):5017-5027.  

 Chemical & Physical Properties

Density 1.54g/cm3
Molecular Formula C9H6N2O3S
Molecular Weight 222.22
Exact Mass 222.01000
PSA 103.43000
LogP 0.85150
Index of Refraction 1.685

 Safety Information

HS Code 2934999090

 Synthetic Route

~92%

4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo- Structure

4,6(1H,5H)-Pyri...

CAS#:27430-18-8

Literature: Paasz, Aleksandra Synthesis, 2010 , # 23 art. no. T12110SS, p. 4021 - 4032

~%

4,6(1H,5H)-Pyrimidinedione,5-(2-furanylmethylene)dihydro-2-thioxo- Structure

4,6(1H,5H)-Pyri...

CAS#:27430-18-8

Literature: Dox; Plaisance Journal of the American Chemical Society, 1916 , vol. 38, p. 2165

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

5-(2-furylmethylene)-2-thioxo-1,3-dihydropyrimidine-4,6-dione
5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
5-furan-2-ylmethylene-2-thioxodihydropyrimidine-4,6-dione
5-furfurylidene-2-thio-barbituric acid
5-Furfuryliden-2-thio-barbitursaeure
5-furfurylidene-2-thioxo-dihydro-pyrimidine-4,6-dione
5-(furan-2'-ylmethylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
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