PRC2 EED-IN-1
Modify Date: 2024-02-25 11:05:51
PRC2 EED-IN-1 structure
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Common Name | PRC2 EED-IN-1 | ||
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| CAS Number | 2762275-20-5 | Molecular Weight | 394.414 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H19FN8O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PRC2 EED-IN-1PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition).PRC2 EED-IN-1 retains efficacy against EZH2 inhibitor-resistant cell lines (Karpas 44 cell IC50=27 nM), exhibits in vivo efficacy in EZH2-driven tumors in vivo. |
| Name | PRC2 EED-IN-1 |
|---|
| Description | PRC2 EED-IN-1 is a potent, selective, allosteric, orally bioavailable inhibitor of the EED subunit of histone methyltransferase PRC2 with IC50 of 44 nM (H3K27me3 inhibition).PRC2 EED-IN-1 retains efficacy against EZH2 inhibitor-resistant cell lines (Karpas 44 cell IC50=27 nM), exhibits in vivo efficacy in EZH2-driven tumors in vivo. |
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| References | 1. Bagal SK, et al. J Med Chem. 2021 Dec 9;64(23):17146-17183. |
| Molecular Formula | C19H19FN8O |
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| Molecular Weight | 394.414 |